The exterior shots of the McGuire family's home were filmed at a real house in Studio City, Los Angeles. The interior scenes were filmed on a sound stage.
Other filming locations in Los Angeles included:
* Hollywood High School, which was used for exterior shots of Lizzie's school.
* Various locations around the city, such as the Griffith Observatory, the Santa Monica Pier, and the Hollywood Walk of Fame, were used for various scenes throughout the series.
While the show was set in the fictional town of Hillridge, New Jersey, the majority of the filming took place in Los Angeles.